Signaling pathways in induced naïve pluripotency
نویسندگان
چکیده
منابع مشابه
Signaling pathways in induced naïve pluripotency.
Pluripotent stem cells have become powerful tools for both research and regenerative medicine. To date, however, only mouse and rat embryonic stem cells (ESCs)/induced pluripotent stem cells (iPSCs) have the ability to contribute to the formation of germline-competent chimeras. These stem cells are thus considered as 'naïve' pluripotent stem cells. Several signaling pathways have been identifie...
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The rodent naive pluripotent state is believed to represent the preimplantation inner cell mass state of the developing blastocyst and can derive self-renewing pluripotent embryonic stem cells (ESCs) in vitro. Nevertheless, human ESCs exhibit epigenetic, metabolic, and transcriptomic characteristics more akin to primed pluripotent stem cells (PSCs) derived from the postimplantation epiblast. Un...
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Embryonic Stem Cells (ESCs) are derived from the inner cell mass of blastocysts. They have the unique potency to differentiate into diverse lineages. Hence, they are bestowed with the term pluripotency. Several mechanisms have been implicated in maintaining the pluripotency of ESCs. This review will focus on the role of signaling pathways in regulating ESC pluripotency among diverse mammalian s...
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Naïve or ground state pluripotency is a cellular state in vitro which resembles cells of the preimplantation epiblast in vivo. This state was first observed in mouse embryonic stem cells and is characterized by high rates of proliferation, the ability to differentiate widely, and global hypomethylation. Human pluripotent stem cells (hPSCs) correspond to a later or "primed" stage of embryonic de...
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ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 2014
ISSN: 0959-437X
DOI: 10.1016/j.gde.2014.08.002